Created in the early days of home computers, and it shows. Here's the plot, near as I can make it. Dr. Brake has developed some sort of weird device that takes a personal item from an animal (or person, though he wanted to limit tests to animals) and turns it into a kind of self-aware metal sphere/pill that rolls and flies around, eventually jumping in the animal's (or person's) mouth to rewrite its DNA, causing profound behavioral changes. Brake's assistant, Julie Clingstone, has the hots for him...and is also evil: She has been conducting dangerous human trials and has sold this tech to a mysterious benefactor.

Meanwhile, Brake's daughter Jessica is super thirsty and determined to get laid, so has started hanging out with the bad boys down at the local saloon. She also has an pet AI daddy built her, in the form of a creepy Kukla-like puppet named George that gives her advice and connects to the (nascent) Internet to remote-control machinery when she needs saving. You can't make this stuff up.

While Brake is away, Julie has invited three college girs up to the isolated mansion for the (nightmare) weekend and uses them as guinea pigs to conduct ever more dangerous and debauched tests, until the whole thing becomes an acid trip: Naked pouncing, spider-kissing, self-mutilations...the works. She reveals her true colors and tries to steal the tech, but is eventually foiled by her ex-lover (now Jessica's) and Jessica herself.

The weekend I watched this was definitely justificaiton for the title.